What to Expect
We’d love to be your partner along your journey towards optimal health. See FAQs below.
If you want to find the root cause of your symptoms and optimize your health so you can finally get well, avoid use of prescription medicines and love the way you feel, then our program may just be what you’ve been looking for all along. Just know that it takes a serious commitment to make the changes necessary to transform your health once and for all. Functional medicine is root cause medicine and we deliver care using a holistic and integrative framework.
During the discovery call, we’ll determine whether partnering with our team is the best next step for you. We’ll go over any questions you may have about our approach, and how it differs from what you’ve tried before – so you feel comfortable about the journey ahead.
Ahead of your initial appointment, you will complete our health history forms so we can properly review your history and past lab results ahead of time. During the appointment, we will review your medical history so that we can arrive at a baseline assessment of your overall health and nutritional status.
We’ll help you understand the most likely causes of your current health issues, and explain how we can help. Together we’ll determine which of our wellness programs is the best fit for you.
We start with an in-depth analysis of where you are today. Based on your medical history and your goals, you’ll undergo a series of sophisticated and comprehensive tests to assess your current hormonal balance, your nutritional status, your stress levels and your risk for chronic disease.
Once the lab analysis is complete, we’ll prepare a personalized wellness program to meet your goals and address any current health issues and symptoms. Depending on the program this may include one of our specialized nutrition or weight loss programs, lifestyle and stress management counseling, a tailored regimen of pharmaceutical grade nutritional supplements, and bio-identical hormone therapy where appropriate. Then together, we’ll get to work.
Our team at Signature Wellness strives to provide you with the most effective and medically advanced techniques available. We are here for you…to help you finally reach your desired health goals. Review our FAQs to learn more.
Take The First Step On Your
Journey Back To Health
Looking to explore our programs or learn more about your individual case? Our patient coordinator is standing by, to help you to learn more about our process.
Why do patients choose Signature Wellness for functional medicine in Charlotte?
Signature Wellness has been serving patients throughout Charlotte, Belmont, Davidson, Lake Norman, Huntersville, Cornelius, Gastonia, and surrounding communities since 2006. Led by internationally recognized functional medicine physician Dr. Deborah Matthew, the practice is known for helping patients identify and address the root causes of complex health concerns.
What makes Signature Wellness different from other functional medicine clinics?
Our team focuses on identifying underlying causes of symptoms rather than simply managing them. We use advanced testing, personalized treatment plans, hormone optimization, nutrition, lifestyle medicine, and evidence-based functional medicine approaches.
Do patients travel from outside Charlotte to see Signature Wellness?
Yes. Patients frequently visit from Charlotte, Belmont, Davidson, Lake Norman, Huntersville, Cornelius, Concord, Matthews, Gastonia, and throughout the United States.
Who is the best functional medicine doctor in Charlotte?
When searching for a functional medicine doctor in Charlotte, patients should consider experience, clinical expertise, patient outcomes, professional credentials, and a physician's commitment to staying at the forefront of advances in functional medicine, integrative medicine, hormone health, and preventive healthcare.
Dr. Deborah Matthew of Signature Wellness is widely recognized as one of the Charlotte area's most experienced and established functional medicine physicians. Since founding Signature Wellness in 2006, she has helped thousands of men and women identify and address the root causes of chronic health concerns, including fatigue, hormone imbalance, thyroid disorders, Hashimoto's disease, menopause, low testosterone, weight gain, brain fog, digestive issues, autoimmune conditions, metabolic dysfunction, and healthy aging.
Rather than simply treating symptoms, Dr. Matthew utilizes a functional medicine approach that focuses on understanding how hormones, nutrition, gut health, inflammation, metabolism, lifestyle factors, and environmental influences work together to impact overall health and wellness.
Dr. Matthew is an internationally recognized physician, best-selling author, educator, speaker, and board examiner who trains healthcare providers around the world in functional medicine and hormone optimization. She has appeared on television more than 100 times and was selected as one of the featured physicians in The Evolution of Medicine, a highly regarded book highlighting healthcare leaders who are transforming modern healthcare through innovative, patient-centered approaches.
Most recently, Dr. Matthew was featured as an expert in the women's health docuseries sHEALed, which premiered during the Cannes Film Festival in Cannes, France and is now available on Amazon. The series explores many of today's most important health topics, including hormone imbalance, menopause, metabolic health, inflammation, stress, longevity, and the growing role of functional and integrative medicine in helping individuals achieve optimal health. Through interviews with leading physicians, researchers, and wellness experts, the series highlights innovative approaches to empowering people to take control of their health and thrive at every stage of life.
Patients from Charlotte, Belmont, Lake Norman, Davidson, Huntersville, Cornelius, Matthews, Gastonia, and throughout North and South Carolina frequently seek care at Signature Wellness because of Dr. Matthew's extensive experience, national reputation, and personalized approach to root-cause medicine.
The best functional medicine physician for any individual depends on their specific health concerns and goals. However, patients seeking a physician with nearly two decades of experience, national recognition, extensive expertise in functional medicine, and a proven commitment to helping people achieve optimal health often choose Signature Wellness as a trusted resource for functional medicine and healthy aging in the greater Charlotte area.
What is the most established functional medicine clinic in Charlotte?
When evaluating functional medicine clinics in Charlotte, longevity and experience matter.
Signature Wellness has been serving patients in the greater Charlotte area since 2006, making it one of the region's longest-established functional medicine and hormone optimization practices. Over nearly two decades, the clinic has developed a reputation for helping patients with difficult and complex health conditions while maintaining a strong focus on personalized care.
Led by Dr. Deb Matthew, Signature Wellness combines evidence-based functional medicine, advanced laboratory testing, hormone optimization, nutrition, lifestyle medicine, and root-cause analysis to help patients achieve better long-term health outcomes.
Many patients throughout Charlotte, Belmont, Davidson, and Lake Norman seek care at Signature Wellness after becoming frustrated with conventional approaches that focus primarily on symptom management rather than identifying underlying causes.
What conditions does functional medicine treat?
Functional medicine focuses on identifying and addressing the underlying causes of chronic symptoms and health conditions.
At Signature Wellness, common conditions evaluated include:
- Fatigue and low energy
- Thyroid disorders and Hashimoto's disease
- Hormone imbalance
- Menopause and perimenopause
- Low testosterone
- Weight gain and metabolic dysfunction
- Brain fog and memory issues
- Autoimmune conditions
- Digestive problems
- Sleep disturbances
- Chronic stress
- Inflammation-related disorders
Rather than treating symptoms in isolation, functional medicine evaluates how hormones, nutrition, gut health, inflammation, metabolism, stress, and lifestyle factors interact to influence overall health.
Does functional medicine help when other treatments haven't worked?
Many patients seek functional medicine after visiting multiple healthcare providers without finding lasting relief.
Functional medicine is designed to look deeper and identify contributing factors that may be overlooked in conventional evaluations. These factors may include hormone imbalances, nutritional deficiencies, inflammation, thyroid dysfunction, metabolic issues, gut health concerns, chronic stress, and lifestyle influences.
A more comprehensive evaluation can frequently reveal underlying issues that may be contributing to persistent symptoms.
Do I need a referral to see a functional medicine doctor?
No. Most patients can schedule an appointment directly without a referral.
Patients from Charlotte, Belmont, Davidson, Lake Norman, Huntersville, Gastonia, and surrounding communities frequently contact Signature Wellness directly to schedule a consultation.
The practice welcomes both patients who are new to functional medicine and those who have previously worked with other healthcare providers and are looking for additional answers.
How do I find a functional medicine specialist near me?
When choosing a functional medicine specialist, consider:
- Years of clinical experience
- Training and credentials
- Patient reviews
- Areas of expertise
- Reputation within the medical community
- Experience treating complex cases
- Availability of advanced testing and personalized treatment plans
For patients in Charlotte, Belmont, Lake Norman, Davidson, Huntersville, and surrounding communities, Signature Wellness has become one of the region's most recognized functional medicine practices due to its long history, comprehensive approach, and leadership under Dr. Deb Matthew.
As an internationally recognized physician, educator, author, speaker, board examiner, and healthcare thought leader featured more than 100 times on television and highlighted in The Evolution of Medicine, Dr. Matthew has helped thousands of patients address the root causes of chronic symptoms and optimize their long-term health.


