Have You Been Told Everything Looks "Normal" But Don't Feel Like Yourself?

Dr Deborah Matthew and Suzanne Somers

Does This Sound Like You?


Brain fog slows you down and destroys productivity on the job.

Fatigue or exhaustion turns basic tasks like laundry and food shopping into grueling chores.

With so little energy, hobbies become a luxury you can’t afford.

Socializing and recreational activities feel impossible under the burden of extra weight.

Finding the Root Cause of your Hormone Imbalance


Our approach to hormone imbalance is different.  We don’t resolve symptoms by first turning to the prescription pad.  Instead, we seek to understand what’s behind the way you feel, so we can correct it. Our primary focus is on finding and treating causes; our goal is long-term solutions. Dr. Matthew is considered a leader by her physician peers in the areas of functional medicine and bioidentical hormone replacement therapy (BHRT). 

Rediscover You. Rediscover Living.


Why Are People Like You Making An Appointment With Signature Wellness?

Watch This Short Video To Hear Deborah Matthew MD Describe Our Approach.

I Want To Love The Way I Feel

Bioidentical Hormone Therapy in North Carolina

Since 2006, Signature Wellness has had the same goal: to help our patients become healthier with the influence of medical science, nutrition and fitness, all provided at the same practice. We provide customized approaches for each of our patients helping them reach the best outcome. 

Searching for Help?



Suffering from Fatigue, Moodiness, Weight Gain, Hot Flashes or Something Else? Are You Tired of Feeling Tired? Have You Been Told Everything Looks Normal?  Does This Sound Like You? Are You Ready To Take Charge of Your Health and Wellbeing?

I Want To Love The Way I Feel

Do You Have A Hormone Imbalance?


Hormone balance has a big impact on our health and our lives. It affects how we feel day-to-day and how we interact with other people. Hormonal problems take many different forms and affect all ages. We have helped women and men in their 20s, 30s, 40s and beyond.

Take the Quiz

Our Philosophy on Functional Medicine


Our practice is not for everyone. It’s true, there is no magic pill for wellness. Our successful patients understand that wellness is a process. If you are ready to take an active role in your journey to health and are ready to get started, click below.

I Want To Love The Way I Feel
Dr. Matthew being featured in NYC Time Square


Can We Help You?


No matter how many doctors you’ve seen or how many pills you’ve tried, it is possible to take back control of your health and your life. Every day we see the transformative power of our programs—profound changes in our patients’ lives. It is so rewarding to see patients regain the energy they’ve been missing, shed those extra pounds, get the sleep they need, and hear them say they look and feel their best again.


I Want To Love The Way I Feel


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Dr. Matthew has been featured on – 

network tv logos
Dr. Matthew & Oprah

with Oprah

Dr Matthew & Jimmy Carter

with Jimmy Carter

Dr Deborah Matthew and Suzanne Somers

with Suzanne Somers

Dr Matthew and Martha Stewart

with Martha Stewart

Deborah Matthew with Deepak Chopra

with Deepak Chopra

Dr. Matthew with Ice-T

with Ice-T and Coco

Deborah Matthew with Tony Robbins

with Tony Robbins

Conference about Cortisol

Speaker at World Congress

Deborah Matthew with Mark Hyman

with Mark Hyman MD

Deborah Matthew with JJ Virgin

Celebrity Nutritionist – JJ Virgin


In Our Patients Own Words…


“Absolutely wonderful,as usual!!”

Sarah M

“The entire staff are very pleasant and always helpful. It is hard to place into words how Dr. Matthew and Staci have made me feel human again!! I can't thank them enough!!

Kim B.

“I always feel very comfortable talking with any of the staff and doctors there. I came in a total mess in February and I'm "leaving" restored. Thank you! All information presented was explained in simple and understandable detail and my road to recovery has been a smooth one because of the new knowledge I've gained through your office.”

Elizabeth J.

“I have in the past and will continue to recommend Signature Wellness to friends and family.”

Barbara M

“My name is Judy and have been a patient of Dr. Matthew and Signature Wellness for 8 years. I always have a warm welcome and the staff is not only wonderful, but very knowledgeable. Thank you Signature Wellness for taking such good care of me.”


“Dr. Matthew and staff have been extremely helpful in addressing some long-term health issues. I was most impressed that I was treated as a “whole person” and given encouragement towards health, not merely treating individual symptoms. I highly recommend Signature Wellness.”


“As always, everybody was super-friendly and helpful. Always great to sit with Dr. Matthew and go over my treatment progress!”

Rudy L.


Read More Reviews

About Dr. Deborah Matthew MD


Dr Deb is an award winning speaker on the topic of wellness and hormones.  She has shared the stage with Suzanne Somers at Harvard and is a Diplomat of the American Academy of Anti-Aging Medicine for whom she is a frequent lecturer.  ABC, NBC, CBS, and FOX TV news and talk shows frequently have Dr Deb on their shows as an expert medical guest. Read more…
Dr Deborah Matthew

Your Next Steps


After you have watched our video about our approach to wellness and if you feel that it makes sense and is right for you,  we would love to hear from you.

Simply schedule a free consultation with our patient coordinator at 704-752-9346 or schedule online below.

Schedule a Consult